The embryonic vertebrate face is composed of similarly sized buds of neural crest‐derived mesenchyme encased in epithelium. These buds or facial prominences grow and fuse together to give the postnatal morphology characteristic of each species. Here we review the role of neural crest cells and foregut endoderm in differentiating facial features. We relate the developing facial prominences to the skeletal structure of the face and review the signals and genes that have been shown to play an important role in facial (...) morphogenesis. We also examine two experiments one at the genetic level and one at the signal level in which transformation of facial prominences and subsequent change of jaw identity was induced. We propose that signals such as retinoids and BMPs and downstream transcription factors such as Distal‐less related genes specify jaw identity. BioEssays 25:554–568, 2003. © 2003 Wiley Periodicals, Inc. (shrink)

We consider a deterministic rewrite system for combinatory logic over combinators , and . Terms will be represented by graphs so that reduction of a duplicator will cause the duplicated expression to be "shared" rather than copied. To each normalizing term we assign a weighting which is the number of reduction steps necessary to reduce the expression to normal form. A lambda-expression may be represented by several distinct expressions in combinatory logic, and two combinatory logic expressions are considered equivalent if (...) they represent the same lambda-expression (up to --equivalence). The problem of minimizing the number of reduction steps over equivalent combinator expressions (i.e., the problem of finding the "fastest running" combinator representation for a specific lambda-expression) is proved to be NP-complete by reduction from the "Hitting Set" problem. (shrink)

Throughout his career, René Girard consistently positioned his mimetic theory as a far more cohesive account of the wide range of phenomena previously addressed by Sigmund Freud, from the nature of human desire all the way to the origin and structure of human culture and religion. Subsequent theories that took shape in psychoanalysis after Freud were not a part of Girard's ongoing discourse for at least two main reasons: Psycho-analysis was seen as a misguided endeavor with fundamentally incompatible concepts and (...) philosophical assumptions, and as psychoanalysis seemed only to be going further in one direction—focusing on the intrapsychic mechanisms of the individual unconscious—Girard's interests went in... (shrink)

The present study assessed the language teachers' pedagogical beliefs and orientations in integrating technology in the online classroom and its effect on students' motivation and engagement. It utilized a cross-sectional correlational research survey. The study respondents were the randomly sampled 205 language teachers (μ= 437, n= 205) and 317 language students (μ= 1800, n= 317) of select higher educational institutions in the Philippines. The study results revealed that respondents hold positive pedagogical beliefs and orientations using technology-based teaching in their language (...) classroom. Test of difference showed that female teachers manifested a firmer belief in student-centered online language teaching than their male counterparts. However, the utilization and attitude towards technology in the language classroom is favorably associated with the male teachers. As to students' level of language learning motivation and engagement, it was found out that male and female students have high level of language learning engagement. Further, the test of relationship showed that the higher the teachers' belief in utilizing student-centered teaching to integrate technology in the language classroom, the higher the students are motivated and engaged in learning. In like manner, it was also revealed that teacher-centered belief is negatively correlated to student’s motivation and engagement in online language learning. In this regard, the pedagogical assumptions that hold EFL teachers positively to integrate technology in the language classroom. This study generally offers implications for enhancing language teacher's digital literacy to promote motivating, fruitful, and engaging language lessons for 21ts century learning. (shrink)

Atomic states are rigorously characterized by the total orbital angular momentum and the total spin angular momentum, but chemists persist in the use of electron configurations based on one-electron quantum numbers and simplified rules for predicting ground state configurations. This practice is defended against two lines of criticism, and its use in teaching chemistry is encouraged with the claim that the inductive approach of Mendeleev and the deductive approach initiated by Schrödinger compose the consummate example of that interaction of empirical (...) and rational epistemologies that defines how chemists think. (shrink)

Contrapower sexual harassment occurs when the target of harassment possesses greater formal organizational power than the perpetrator. Traditional conceptualizations of power underlying sexual harassment have either focused on location within organizational hierarchies or sociocultural status differences between men and women. We suggest the utility of simultaneously considering the influence of gender, race, and class on power dynamics at organizational, sociocultural, and interpersonal or individual levels. Using qualitative data obtained from 8 focus groups, 20 interviews, and 1 in-depth case study, we (...) examine how gender, race, and class influence varied sources of power available to perpetrators and targets in workplace contrapower situations. We argue that the exploration of the dynamics involved in contrapower sexual harassment can illuminate broader processes of doing gender and power in the workplace. (shrink)

SummaryIntense, sustained nursing lengthens inter-birth intervals and is causally linked with low natural fertility. However, in traditional settings, the effects of such nursing on fertility are difficult to disentangle from those of nutrition. Results from an prospective, direct observational study of reproductive function in well-nourished Amele women who nurse intensively and persistently but who also have high fertility are here presented. Endocrine measures show that ovarian activity resumes by median 11·0 months postpartum. Median duration of postpartum amenorrhoea is 11·3 months, (...) time to next conception is 19·0 months, and the inter-birth interval is 28·0 months. Average life time fertility is 6·8. High fertility in Amele women is due both to refractoriness of reproductive function to suckling stimuli, and to maintenance of equivalent age-specific fertility rates across the reproductive life span. (shrink)

People with disabilities face inequalities in mental wellbeing, for which social exclusion is a contributing factor. Musical activities offer a promising but complex intervention, making impacts on a population with highly varied characteristics and needs challenging to capture. This paper reports on a mixed methods, person-centered study investigating a community music intervention for such a population. Three groups of adult service users with varied disabilities, took part in weekly music workshops in different locations. Music staff, housing and resource center staff, (...) as well as participants and members of their families, took part in semi-structured interviews. A quantitative measure administered by service staff was used to rate service users’ social development. Two lay researchers, both individuals with a disability contributed to all aspects of the study. Interviews were analyzed through thematic analysis. Improvements in individuals’ self-expression, confidence, mood, and social skills were consistent with previous findings. Differences in effect between centers included: Group 1, some of whom had previous experience of workshops, showed an improvement in musical skills; Group 2 showed a mixed response, some participated with enthusiasm but others chose art activities over music workshops; Group 3 had lasting positive impact, this group had very limited opportunities for music due to their rural location. Quantitative analysis showed significant increase over all groups in communication, interaction with others, and joint attention. The intervention was beneficial for participants in separate locations in similar ways, but also highlighted that context and prior experience mediated effects in distinct ways. The lay researchers enhanced the qualitative analysis by emphasizing the importance of recognizing participants’ self-expression in non-verbal modes of communication and the importance of having music staff with a disability to provide a positive role model. This paper proposes that mixed methods person-centered research is the most suitable approach to capture and understand the multiple and varied effects of this complex intervention for a diverse group of participants. (shrink)

This collection of essays is dedicated to the prolific career of Paul Ricoeur. Honoring his work, this anthology addresses questions and concerns that defined Ricoeur’s.

Over the past decade, Convergence Research has increasingly gained prominence as a research, development, and innovation (RDI) strategy to address grand societal challenges. However, a dearth of research-based evidence is available to aid researchers, research teams, and institutions with navigating the complexities attendant to the specifics of Convergence Research. This paper presents a multilevel research agenda that accounts for an integral understanding of Convergence Research as a complex adaptive system. Furthermore, by developing a framework that accounts for ancillary, yet essential, (...) systems associated with Convergence Research, we enrich the agenda with a literature-steeped discussion that considers how systems-based practices of collaboration, inquiry, and context interact with the processes and products of Convergence Research. Finally, we synthesize and apply insights from the reviewed literature by providing paths for empirical exploration emphasizing systems-based practices. In so doing, we delineate an extended boundary for a research stream that both clarifies and enlarges our understanding of Convergence Research as a ‘system-of-systems’. (shrink)

This article attempts to answer a question that many dancers and non-dancers may have. What is dance according to the media? Furthermore, how does the written word portray dance in the media? To answer these ques-tions, this research focuses on the role that the discourse of dance in media plays in the public sphere’s knowledge construction of dance. This is impor-tant to study because the public sphere’s meaning of dance will determine whether dance education is promoted or banned in schools (...) and in society. The aim of this paper is to contribute to the existing literature of dance in the media. One limitation of this contribution is that the research uses only newspaper articles as a source of analysis. Future research should include an analysis of visual and audio clips of dance as portrayed in the media. (shrink)

In Spoils of War, a diverse group of distinguished contributors suggest that acts of aggression resulting from the racism and sexism inherent in social institutions can be viewed as a sort of "war," experienced daily by women of color.

In this volume _Grace M. Jantzen_ continues her groundbreaking analysis of death and beauty in western thought by examining the religious roots of death and violence in the Jewish and Christian tradition, which underlie contemporary values. She shows how man’s fear of the female is often implicated in religious violence and in her critique of the Hebrew Bible and the Christian New Testament she examines a range of themes that show the western preoccupation with necrophilia. She examines the relation of (...) death to the Jewish covenant, the nature of monotheism, Holy War and the Christian covenant and kingdom. However, Jantzen recognises that submerged beneath these themes in Judaism and Christianity are traces of an alternative world of beauty and life. Jantzen’s internationally recognised feminist philosophy of religion puts forward a powerful analysis of patriarchy and violence and reveals the hidden power of natality. Her work is a searching challenge for our times and one that gives hope in a violent world. This work is the first of two posthumous publications to complete her impressive genealogy death and beauty of western thought. (shrink)

In this book Grace Jantzen constructs a Quaker spirituality of beauty as a theological-philosophical response to a world preoccupied with death and violence. Having mapped the foundations of western cultural violence in the Greco-Roman period and the Judea-Christian tradition in _Foundations of Violence_ and _Violence to Eternity_, she now offers her alternative vision. This vision is an original and creative feminist reading of the Quaker tradition, considering George Fox and the writings of Quaker women, exploring the themes of inner light (...) and beauty as alternatives to violence and the obstacles to building such an alternative world. After showing how seventeenth-century Quakers offered a different option for modernity, she maps the philosophical and ethical implications of engaging with the world through beauty and its transforming power. Written for everyone interested in contemporary spirtuality, it explains how Quaker ideas can provide a way to transform our violent world into one that celebrates life rather than death, peace rather than violence. This work is the second of two posthumous publications to complete Grace M. Jantzen’s _Death and the Displacement of Beauty_ collection, which began with Foundations _of Violence_. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:The Ethical, Legal, and Social Implications Research Program at the National Human Genome Research InstituteEric M. Meslin (bio), Elizabeth J. Thomson (bio), and Joy T. Boyer (bio)Organizers of the Human Genome Project (HGP) understood from the beginning that the scientific activities of mapping and sequencing the human genome would raise ethical, legal, and social issues that would require careful attention by scientists, health care professionals, government officials, and the (...) public. The establishment of the ELSI (ethical, legal, and social implications) programs at the National Human Genome Research Institute (NHGRI) and the Department of Energy (DOE) was thought to be vital to the success of the HGP in the United States. It also provided a novel approach to the simultaneous study of ethical, legal, and social issues and basic scientific issues. Eric Juengst, the first director of the ELSI program, described its origins in a previous issue of the Kennedy Institute of Ethics Journal (Juengst 1991). Now in its seventh year, the ELSI program has accomplished much. This article summarizes the evolution and goals of the ELSI program at NHGRI, outlines the program’s current research priorities with examples of activities within each priority area, and provides a look to the future, including the initiation of a strategic planning process.Evolution and Goals of the ELSI Research ProgramThe HGP’s “genomic” goals are unique: to map and sequence the entire human genome—some 3 billion base pairs that make up approximately 80–100,000 genes—and the genomes of related model organisms by the year 2005. This goal was particularly ambitious since, when it was proposed, the technologies for mapping and sequencing had yet to be developed. When the HGP was first established, its organizers also elaborated a set of ELSI goals, which they saw as vital to the success of the genome project. The original ELSI goals were: (1) to anticipate and address the implications of the HGP for individuals and society and (2) to examine the ELSI consequences of mapping and sequencing the human genome in order to stimulate public discussion. To meet these goals, the NHGRI created its ELSI research program in 1990. Along with mapping, sequencing, [End Page 291] and mammalian genetics, ELSI was one of four original branches in the NHGRI Division of Extramural Research that funded research in those areas. Although the individual “branches” no longer exist, the mechanisms for funding research remain much the same. While the overall goals of the program have not changed, the specific ways of achieving the goals have continued to evolve. The importance of the ELSI program lies not in the collection of a full set of data that will be valuable in and of itself, but in the value of using and interpreting this new set of information.Early on, the NHGRI described a set of somewhat more specific goals: (1) to develop a program to help understand the ethical, legal, and social implications of the human genome project and (2) to identify and define the major issues of concern and develop policy options to address them. These more specific goals have been largely met. As the most recent biennial NHGRI Progress Report notes, “a robust ELSI research and education program has been established, many of the most urgent ELSI issues have been identified, and many policy options to address these issues have been proposed” (NCHGR 1995, p. 21). Between 1990 and 1996, ELSI provided more than $32.5 million in funding through 128 research and education grants in more than 30 states and in Canada (Table 1). The ELSI research budget is unique in that when originally created, it was specifically tied to the amount of money provided for the overall NHGRI budget. The NHGRI originally devoted 3 percent of its extramural budget to fund ELSI projects, but in FY 1991, it increased the ELSI budget to 5 percent, a figure that remains today. Table 2 lists the expenditures for each fiscal year since 1990 and the cumulative expenditures to date. The ELSI research budget at NHGRI this year will be about $7 million. When other sources of funding—e.g., co-funding arrangements with other institutes and agencies and the funding of ELSI... (shrink)

Part I Introduction -/- Passion at a Distance (Don Howard) -/- Part II Philosophy, Methodology and History -/- Balancing Necessity and Fallibilism: Charles Sanders Peirce on the Status of Mathematics and its Intersection with the Inquiry into Nature (Ronald Anderson) -/- Newton’s Methodology (William Harper) -/- Whitehead’s Philosophy and Quantum Mechanics (QM): A Tribute to Abner Shimony (Shimon Malin) -/- Bohr and the Photon (John Stachel) -/- Part III Bell’s Theorem and Nonlocality A. Theory -/- Extending the Concept of an (...) “Element of Reality” to Work with Inefficient Detectors (Daniel M. Greenberger) -/- A General Proof of Nonlocality without Inequalities for Bipartite States (GianCarlo Ghirardi and Luca Marinatto) -/- On the Separability of Physical Systems (Jon P. Jarrett) -/- Bell Inequalities: Many Questions, a Few Answers (Nicolas Gisin) -/- B. Experiment -/- Do Experimental Violations of Bell Inequalities Require a Nonlocal Interpretation of Quantum Mechanics? II: Analysis a la Bell (Edward S. Fry, Xinmei Qu, and Marlan O. Scully) -/- The Physics of 2 = 1 + 1 (Yanhua Shih) -/- Part IV Probability, Uncertainty, and Stochastic Modifications of Quantum Mechanics -/- Interpretations of Probability in Quantum Mechanics: A Case of “Experimental Metaphysics” (Geoffrey Hellman) -/- “No Information Without Disturbance”: Quantum Limitations of Measurement (Paul Busch) -/- How Stands Collapse II (Philip Pearle) -/- Is There a Relation Between the Breakdown of the Superposition Principle and an Indeterminacy in the Structure of the Einsteinian Space-Time? (Andor Frenkel) -/- Indistinguishability or Stochastic Dependence? (D. Costantini and U. Garibaldi) -/- Part V Relativity -/- Plane Geometry in Spacetime (N. David Mermin) -/- The Transient nows (Steven F. Savitt) -/- Quantum in Gravity? (Michael Horne) -/- A Proposed Test of the Local Causality of Spacetime (Adrian Kent) -/- Quantum Gravity Computers: On the Theory of Computation with Indefinite Causal Structure (Lucien Hardy) -/- “Definability,” “Conventionality,” and Simultaneity in Einstein–Minkowski Space-Time (Howard Stein) -/- Part VI Concluding Words -/- Bistro Banter: A Dialogue with Abner Shimony and Lee Smolin -/- Unfinished Work: A Bequest (Abner Shimony) -/- Bibliography of Abner Shimony. (shrink)

What if human joy went on endlessly? Suppose, for example, that each human generation were followed by another, or that the Western religions are right when they teach that each human being lives eternally after death. If any such possibility is true in the actual world, then an agent might sometimes be so situated that more than one course of action would produce an infinite amount of utility. Deciding whether to have a child born this year rather than next is (...) a situation wherein an agent may face several alternatives whose effects could well ramify endlessly on such suppositions, for the child born this year would be a different person—one who preferred different things, performed different actions, and had different descendants—from a child born next year. It has recently been suggested that traditional utilitarianism stumbles on such cases of infinite utility. Specifically, utilitarianism seems to require, for its application, that all experience of pleasure and pain cease at some time in the future or asymptotically approach zero.2 If neither of these conditions holds, then the utility produced by each of two alternative actions may turn out to be infinite, and utilitarianism thus loses its ability to discriminate morally between them. (shrink)

Even strong, fearless, and badass Black girls and Black women need affirmations-- now more than ever. Fievre shares inspirational words of wisdom through fabulous Black female trailblazers who changed the world. You don't always have to be strong. Sometimes taking a break to focus on your mental health is bravery in itself. We find ourselves needing reminders that we are incredible and more than enough. Fievre shares strategies that will give you the dose of radical self-affirmation you deserve. -- adapted (...) from back cover. (shrink)

No speech in Attic tragedy has made a stronger impression on later generations than Medea's farewell to her children. Four changes of mind and two displays of maternal affection lay bare the depths of a tortured soul; ‘there, in a short space, arelove and hatred, firmness and hesitation, fierce joy and unfathomable sorrow’.

The article analyzes the little-known field of philosophical studies of M. Schlick, who was traditionally considered as a scientist dealing with the problems of epistemology and philosophy of science. In the spotlight of the research is the work On meaning of Life, where the philosopher not only lays the foundation for his future work on ethics but also offers an original approach to the problem of the meaning of life, linking it with the concept of "youth". He notes that most (...) people see the meaning of life in achieving certain goals. As a result, life is filled with activities aimed at preserving existence. The only way to find meaning in life is through an activity that has a purpose and value in itself, so the meaning of life cannot be found in work since it is not an activity for its own sake. The alternative is the game inherent in youth. It fills you with joy and gives value to life. The meaning of life symbolizes youth. You can be young at any time if you consider youth as a time of play, activity and creativity. It implies the requirement to change the conventional system of upbringing and conservative ethics. In particular, he insists that it is necessary to abandon the ethics of duty and replace it with new ethics, where the virtue is serene, does not suffer from the pressure of duty and freely unfolds of its own will. It is concluded that Schlick's ethics of youth is symptomatic of the first third of the twentieth century since those times were oriented to the new man, whose universal traits were health, cheerfulness, fortitude and social activism. (shrink)

This paper aims at explicating the role of the connections and interactions between health, well being and beauty. The primary goal of all medical approaches, including the classic biomedical and humanistic or humane approaches, is to restore or create health, whereby medical approaches that include prevention go beyond the mere restoration of health to include the preservation of health. Equating well-being and thus health with a largely self-determined and joyful life, then not only does a healthy life become a beautiful (...) life, a beautiful life also becomes a healthy life! By bringing Beauty into the health discourse, we are entering the field of aesthetics in general and social aesthetics in particular. As the beautiful is not just a decorative element of life but a genuine source of human strength, it gives us the strength and power we need to implement and achieve all that we then experience as “well-being” and that is called a healthy life. Therefore a further development of a human-based medicine is needed, a medicine that focuses not on a disease construct but which places a human being as a whole, with all his potential and limitations at the heart of diagnostic and therapeutic efforts. The noblest therapeutic goal of this kind of medicine can only be the restoration or preservation of a comprehensive state of health in the sense of complete physical, mental and social well-being, in the sense of opening up the possibility for a mostly autonomous and joyful life. (shrink)

This book examines the significantly similar, yet finally different, thinking of two nineteenth-century existentialist thinkers, Soren Kierkegaard and Friedrich Nietzsche. Its focus is on the different ways each envisioned a joyful acceptance of life - a concern they shared. Each strove to give a place to this acceptance in his picture of life, but their conceptions of it are far apart.

The many conflicting views that have given rise to the contemporary crisis in religious thought can be traced to certain figures who have played a major role in the shaping of present-day thinking. An exploration of the ideas of these philosopher-theologians, from Schleiermacher and Kierkegaard to Barth, Tillich, Maritain, Berdyaev, Buber, and such lesser figures as Dietrich Bonhoeffer, Harvey Cox, Thomas Altizer, and Richard Rubenstein, has been the chief objective of the author of this work. His survey of modern and (...) contemporary religious thinking, which he conducted within a predominantly Protestant framework, has convinced him that a common theme runs through the writings of the men examined by him: the problem of God is inseparable from the problem of modern man. "In the minds of theologians," the author asserts, "the loss of certainty about God is at base a loss of a sense of ultimacy which gives depth and purpose to everyday living.... And so, in responding to the loss of ultimacy, modern theology has reintroduced the question of man himself: his life and death, his experiences of tragedy, joy, guilt, acceptance, loss, and love." While pointing to the radical differences among theologians in their explanations of man's loss of faith, Idinopulos suggests that the theological options offered by such men as Barth, Tillich, Maritain, Berdyaev, and Buber are of paramount importance for the understanding of today's religious thinking. In his final chapter, the author makes a critical appraisal of the chief representatives of "secular theology," such as Bonhoeffer, Cox, and Altizer; and analyzes Rubenstein's peculiar theory of Holy Nothingness, or "Sacred Void out of which we came and to which we return." The author's analysis makes clear the extreme confusion, and even outright absurdity, into which men have been led by the self-styled "Theologians in a World Come of Age," which is the title of the chapter. The volume closes with a selected bibliography for each of the authors discussed and a comprehensive index.--B. M. B. (shrink)

The second of these lines seems to be the result of an interpolation designed to spell out the implicit sense of the first. In 241–6 Ion has expressed amazement that Creusa should be weeping at the sight of Apollo's sanctuary, a sight which brings other visitors joy. She prefaces her explanation of this with an assurance which in its transmitted form is elegantly translated by Grégoire: ‘Il n'est point discourtois de ta part, étranger, de marquer ta surprise au sujet de (...) mes pleurs.’ But there are reasons for doubting I the authenticity of line 248: Line 247 is self-sufficient, as is shown by IA 1402: τ μν σόν, νενι, γενναίως χει. This also gives the closest parallel for the use of τ σόν in reference to the attitude which a previous speaker's words have just expressed. Other instances of τ σόν, tout court, are helpfully grouped in Allen and Italie's Concordance to Euripides, s.v. σός. τ σόν…[adverbial phrase] χει occurs also in Hek. 1195 and Med. 312; cf. HF 165, Hel. 893, Pho. 995 with τομόν. These make it unlikely that τ χόν in our passage is to be taken adverbially, as perhaps Grégoire intended with ‘de ta part’, rather than as subject of χει. Tro. 82 might be adduced for the alternative , but there is no reason for Creusa to be saying emphatically ‘as far as you are concerned’. (shrink)

Using a critical postmodern framework, this article analyzes the relationship of the decision-making processes of anarchism and neoliberalism to that of deep democracy. Anarchist processes are found to share common core principals with deep democracy; but neoliberal processes are found to be antithetical to deep democracy. To increase the joy in learning and teaching, based upon this analysis, practical anarchist guidelines for school decision-making are suggested.

Back‐to‐back papers have described the identification of a family of receptors for the plant hormone auxin.(1, 2) Most developmental processes in plants are dependent on auxin signalling making this discovery a landmark in the search for the mechanism of auxin action. The TIR1 gene translates into a protein with recognised motifs including an F‐box domain and TIR1 forms part of an important ubiquitination complex that tags other proteins for degradation.(3) Specific amongst the targets of TIR1 are a set of auxin‐regulated (...) transcription factors.(4) The latest work has shown that TIR1 itself is also the binding site for auxin making it an auxin receptor with no requirement for a biochemical signalling cascade. BioEssays 27:1213–1217, 2005. © 2005 Wiley Periodicals, Inc. (shrink)